肽类在运动损伤修复和脑部保护中的应用
@ @Kyle : 职业运动员经常使用肽来加速从剧烈运动和损伤中恢复。澳大利亚媒体过去对肽类持负面看法，但现在肽类越来越受到关注。制药公司可能试图修改肽类以获取商业利益。缺乏长期人体研究是一个问题，但运动员的经验和对作用机制的理解使得进一步研究的必要性降低。UFC运动员使用BPC可能面临禁赛风险，因为其能带来不公平的优势。 Sim: 肽类在脑部保护方面具有潜力，尤其是在预防脑震荡和支持运动员的长期健康方面。
我最近与Kyle进行了一次深入的访谈，探讨了肽类在运动表现和健康，特别是脑部保护方面的作用。这次对话让我对肽类的潜力有了更深刻的认识，也让我意识到一些阻碍其广泛应用的挑战。
Kyle的经历尤其引人注目。他创立了一家肽类公司，最初在澳大利亚运营，但由于政府对肽类的严格监管，最终将业务转移到了美国。澳大利亚曾因职业运动员使用肽类而对其进行全面禁止，媒体的负面报道也加剧了公众的误解。然而，如今肽类已逐渐获得认可，这与运动员们广泛使用肽类来加速恢复和修复组织的现象密不可分。
我们讨论的核心问题之一是肽类的监管。Kyle认为，制药公司可能试图控制肽类市场，因为天然存在的肽类难以获得专利保护。这导致了对肽类进行长期人体研究的资金投入不足，尽管动物实验和运动员的经验性证据已经表明了其有效性。 这无疑是一个需要解决的瓶颈，因为缺乏大规模临床试验数据，限制了肽类在更广泛医疗领域的应用。
在运动领域，特别是对抗性运动，肽类的作用尤为重要。例如，BPC-157常被用于修复组织损伤，但其在UFC等运动中被列为禁用物质，因为其能显著加快恢复速度，从而带来不公平的竞争优势。 这凸显了在体育运动中平衡肽类应用的必要性，既要承认其在促进运动员健康和延长职业生涯方面的益处，又要避免其被滥用以获得不公平的优势。
谈话中，我们还深入探讨了肽类在脑部保护方面的应用。Kyle强调了地黑沙(Dihexa)和P21等神经肽在预防和治疗脑损伤方面的潜力。这些肽类能够保护运动员免受长期脑损伤的风险，尤其是在诸如美式橄榄球和UFC等高冲击性运动中。这为运动员的长期健康提供了新的保障，也为脑部疾病的治疗提供了新的方向。
Kyle的公司专注于口服肽类，这与市场上常见的注射型肽类有所不同。他解释了口服肽类的生物利用度虽然低于注射型，但通过改进递送方式（例如脂质体包裹），可以显著提高其吸收率。这为肽类的应用提供了更大的便利性，也提高了患者的依从性。
最后，Kyle分享了他个人的经验，以及他创立公司的初衷。他最初接触肽类是在一家生物黑客诊所工作期间，目睹了肽类在治疗慢性疾病和促进运动员恢复方面的显著疗效。这促使他深入研究肽类，并最终创立了自己的公司。他的经历也反映了肽类在未来医疗保健和运动医学领域中所蕴含的巨大潜力。 肽类的研究和应用仍处于发展阶段，但其在运动表现提升和脑部保护方面的潜力不容忽视。 未来，更深入的研究和更合理的监管将推动肽类在更广泛领域的应用，造福更多的人。
Edit:2025.07.07
00:00
American football, any sport really, UFC being probably the epitome in boxing, having that peptide or the neuropeptides like dihexyl or P21, cerebral lysine, having those preventatively or immediately after those events would just be an amazing way to
00:14
protect the athlete for the rest of their life. But about 80% of what you take as far as the BPC goes, 80 to 90 will be absorbed if you use that form. Then there's other ones like all the growth hormones, secretagogues, you know, CJC and hippomoralin. None of these are going to work orally. They need to be injected. Kyle, welcome to the show. Thanks for having me on, Sim. Nice to be on and I've been a fan of yours for years and listen to your YouTube videos and podcasts. So it's an honor for me to be on here chatting with you.
00:43
Yeah, and I'm also excited because you have a very interesting peptide company which does things a bit differently than other peptide companies and a lot of very fascinating cutting-edge ingredients and peptides that we'll go through in this podcast. But maybe we can start with… My biggest question is like…
01:05
So you're based in Australia or companies in Australia. What is the situation with the government and the legal stuff with peptides in Australia? Because the peptides aren't like your regular GNC supplements that you can get. Yeah. So the business is no longer in Australia. To be very clear about that, we had BPC-157 get banned in June of 2024, which was when I first…
01:33
visited America with the brand. So since then we had to stop selling the peptides to Australia and then we've transitioned to have all manufacturing in America and the business has operated from there now. So where the regulations in Australia were very restrictive, they always have been around supplements in general, but peptides actually got, some of them got banned all the way back as early as 2006. Ones like
01:58
thymus and beta-4 TB500 got banned because a professional sporting team, a football team in Australia were using it on all their athletes and getting significant muscle gain and recovery results and did incredibly well. And then they investigated that they were injecting all these peptides, which the media treated as if they were injecting testosterone or something credibly illegal or that's clear violation. So they retrospectively banned
02:26
peptides and banned all the players for using them for gaining an unfair advantage. They were using things like CJC, um, TB 500 and even injectable things like colostrum and ginseng too. They were doing some advanced biohacking back nearly 20 years ago now. And, um,
02:43
That was kind of my first ever introduction to peptides, and it wasn't particularly a nice one because the Australian media made them out to be these horrible things that are going to cause all manner of side effects and problems. But here we are 20 years later, and now everyone's talking about peptides, which is good, but very frustrating in my former country that they had such a closed-minded nature to it and tried to cut the head off the snake all the way back then. Yeah.
03:11
Yeah, it's very fascinating because pretty much all the pro athletes use it. A lot of them, in UFC, you probably have every one of them use BPC and other peptides to support recovery and tissue repair. So a lot of these pro athletes use it with their coaches, but the government still kind of try to… I don't know what's the issue. Is it that…
03:40
Is it something related to lack of research or is it something just fear or ignorance or not knowing what these peptides actually are? Because, yeah, they're not testosterone. They're not anabolics. They're not performance-enhancing drugs. They're amino acid chains that are relatively benign. Yeah, exactly. They're naturally occurring. They're bio-identical to what our body makes naturally. So why ban them? Well, my first…
04:07
immediate thing is the pharmaceutical companies want to modify them like they have GLP-1s, like they're trying to do now. And you can't make a drug if it's naturally occurring and readily available. So in my opinion, they're trying to now ban them, meanwhile spending millions of dollars developing drug-like peptides. As soon as BPC-157 can be
04:31
done the same way GLPs are, where you maybe inject it or you take it and it lasts a whole week, then you know for damn sure that every pharmaceutical company that can do it will be doing that and making similar amounts of money as they have with the GLP ones, maybe less. So that's, as an overarching theme, probably why. But yeah, I do have to acknowledge there's a lack of human studies. There's been a few goings
04:53
going around, but none of them are really long-term and nor will there be unless companies like mine and others collaborate and spend a lot of money doing those multi-million dollar extended trials on peptides. No one's willing to spend that when it's just going to get used by every single company that does it. Essentially, you're just giving away money, which would be a good thing. The only way I could see it happening is if someone like RFK or someone that minded decided that
05:21
the government's going to spend money researching these things because from a private business perspective and even a research perspective, you're not going to be able to patent what you spent millions of dollars studying. Therefore, why would you do it and just essentially give money to other companies? Yeah. Yeah, that's unfortunate that if you do a study, let's say, on ingredient X, even like a regular supplement, you do a study on, I don't know, azaxanthin, you spend millions of dollars on the clinical trial and you get outcomes that, okay, it improves this marker this much
05:50
then all the other companies who never paid for the clinical trial can use this study to also sell as the exact thing so yeah like it's not a good business move to actually fund your own clinical trials with the peptides but yeah you know i think uh idea you know you know let's say hopefully we would get some sort of uh clinical trial with critical trials with these peptides because there's a lot of this anecdotal experience and like i said all these pro athletes pretty much use them
06:15
on a regular basis to speed up recovery from their strenuous exercise and injuries. So there is definitely a lot of, you can call it anecdotal evidence, but there is some evidence that they do work for a lot of things. That's the thing that I've noticed too is people don't really need to even see the studies now. It's been trialed and there's been enough
06:39
of the population and people of significance try these things, see the benefits and be like, well, this is mechanistically how it worked in animals. They can, they're not the same species, but the mechanism is the same in humans. Therefore, why do we need to spend all this money proving what we already know? For a newer
06:57
newer peptides, ones that aren't like the commonly used ones like BPC or GHK copper, I believe there'll probably be a place for that. But for now, yeah, you don't really need to do it. I will clarify one thing too, that if UFC athletes are taking BPC, they're probably going to get in trouble. It is water banned now because it elicits an unfair advantage in sports, i.e. you're going to heal a lot faster than someone who doesn't take it. Therefore, they ban it rather than allowing it for everyone, which would be a lot more common sense
07:26
than just not letting anyone use it, especially sports where you have risk of…
07:32
brain injury, concussion, TBI, like American football, any sport really, UFC being probably the epitome in boxing, having that peptide or the neuropeptides like dihexa or P21, cerebral lysine, having those preventatively or immediately after those events would just be an amazing way to protect the athlete for the rest of their life because professional sportsmen, sportswomen,
07:56
have only a 10 to 15 to 20 at max year span of that career and then they put their body through all these knocks and injuries and you know one of those things can cut their career in half and then
08:09
ruin the rest of their life if it's something like american football where they get those micro concussions something like bpc and cerebral lysine could almost prevent those i'm not saying it will but like they're mechanistically the sort of things that really should be taken and be used to prevent those future negative outcomes yeah like contact sports is associated with shorter lifespan as well uh
08:32
out of all other sports and yeah just supporting the recovery from those injuries and reducing the oxidative stress that you experience that you from the concussions and other damaging injuries then it just makes the athlete healthier and and reduces their risk of all these other chronic diseases as well that they will that they will get from being a professional athlete in contact sports yeah
09:00
the bodybuilders are the ones who are the kind of have a free pass to use anything that makes them muscular but even the peptides like no one really cares if you're ingesting injecting tremolone and testosterone a peptide's the least of the safety concerns and in fact doing them concurrently is probably going to help those people have an extended career i know people like chris bumstead do a
09:22
peptides like almost on repeat always just to increase the growth hormone density um for helping heal their recovery for their recovery but also up regulating all the collagen networks and the connective tissue that it works on primarily whilst also doing the tb400 uh the tb4 or tb500 which works on more the musculoskeletal so they're getting he's getting an amazing results from these peptides having absolutely ruined his body in the pursuit of you know
09:51
perfection from a bodybuilding perspective and good on him for doing that. And it's, you know, I believe all sports should do it. So I'll stop being so philosophical about peptides. I just love them so much. And they've had such a profound impact on, on my life personally, um, on the thousands of people who've tried them, especially people with IBD issues and gut issues. That's sort of been the focus of a lot of the, the, uh, the products within my range, but like,
10:18
And recently too, with Alzheimer's and neurodegenerative conditions, I brought out ones to help and support the brain too. And we can talk about those a little later.
10:27
Yeah. What made you get into peptides and start a peptide company? Because it's not a very charitable or favorable company to start. It's much easier to start a regular supplement company. Yeah, especially not in Australia, where it, again, was very restrictive. So the first few years of business, I was kind of just waiting for it all to be shut down. And then
10:51
never really happened until 2024 when they just banned the peptides. And, you know, by that point we had enough momentum behind the business to keep it going. But what got me into it was working at a hyperbaric oxygen facility. It was in Melbourne in Victoria. And the
11:07
The facility was really cutting edge. It had hyperbaric cryotherapy, red light therapy, carbon dioxide chambers. I've forgotten what those are called. Vibration plates. It was like a biohacking facility. And across the road was a peptide compounder.
11:23
And a lot of the patients would come in with things like Lyme disease or cancers, or they'd be athletes, for example, like tennis players like Novak Djokovic would come in and we'd deal and help them with their hyperbarics and some complementary modalities. But a lot of the chronic disease patients would come in and tell me all about what they're taking, all the supplements. And at the time I was studying to be a naturopath, so I was really interested in the herbs and suggesting that. And they're like, yeah, I've tried those. They worked a little bit, but these peptides have been an absolute game changer.
11:52
So that's when I just dove really deep down the peptide rabbit hole and had the opportunity to start with BPC. That was the first product the brand ever sold. And from then I've just obsessed over them and built out the range with whatever's worked for me personally, always trialing them on myself first.
12:12
Um, if they don't really work, I don't tend to make them. But, you know, uh, from then it was after that, it was a housemate of mine had Crohn's disease, gave her some BPC and she was like, oh yeah, it's all right. And
12:25
But I didn't feel like it was specifically targeting all of the hallmarks of IBDs. So that's when the second product I developed was the Ultimate GI Repair, which now has four gut healing peptides and all those naturopathic botanicals that I was learning about whilst at the hyperbaric clinic. So that's how I got my start. The naturopathic school, nutrition school, and then working in the functional medicine space in that hyperbaric facility. Gotcha. Yeah.
12:53
Yeah, you chose the route of oral peptides rather than injectable that most or it's most commonly used. So one of the biggest, I guess, arguments people say that are the oral peptides then as effective and as bioavailable? Yep. No, they're not. They're close depending on how you deliver them and which one you take. Something like a BPC-157 is
13:17
The things to consider for that are what form of BPC-157 are you taking? There's three common. I'd actually argue only two common now. It's like the acetate form, which is what people will inject. It's significantly cheaper, but it's not very stable when you do it orally in a capsule or just as a liquid. There's the BPC-arginate, which I don't recommend you don't need to inject that one because the acetates are way cheaper. But that one has been studied and proven when it was actually used
13:46
decade or so ago a trademark form called Diogen. They did a lot of studies on proving that it would be able to survive the stomach acidity and actually work orally. So roughly, it depends on everyone's biology, but about 80% of what you take as far as the BPC goes, 80 to 90 will be absorbed if you use that form.
14:08
of BPC, but then there's other ones like all the growth hormone secretagogues, you know, CJC and hipomoralin. None of these are going to work orally. They need to be injected unless we can in future find an active fragment of it that's small enough and stable enough to absorb through the stomach, through the gut lining after surviving the stomach acid and all the enzymes that work on, act on these peptides. Insulin is another peptide that, you know,
14:35
diabetics still inject it because it's too large. And if you break it down into smaller fragments, it now, it then loses its function and its effect. So that for now still needs to be done injectably. And that's, I think I see peptides heading towards the oral route of administration just because of compliance and simplicity and needle phobia, which is a reasonable thing. Even if you're not scared, it's just tedious to do that on repeat all the time. So
15:03
Yeah, I think the future of peptides and the future of medicine will be oral peptides. They've even tried oral semaglutide and GLP-1s and they can get them to work to some level of effectiveness. You're definitely going to lose a significant amount versus injectable, which is always going to be 100%. There's no argument on my part that injectable is the better way to do it, but my business is based on the fact that people
15:28
People don't like doing injectables, nor do I. So any one of the peptides that you can make work orally, that's what we sell and that's what I use. Like TB500 is the synthetic peptide that helps with musculoskeletal injury and healing. That peptide's too large, so we use the fragments of the naturally occurring TB4. They're called the AC fragments. Those are four and seven amino acid long sequences within that parent peptide.
15:57
If you liposome them like we do and also protect them from that stomach acid and the proteolytic enzymes, now you have TB500 that will work orally if you take it versus having to inject it. So again, it's not going to be as effective, but you dose it up. So accounting for some degree of loss and then you basically get the benefits of having done an injectable without the need for the needles. Yeah, the oral rotamil.
16:24
makes it so much easier and like I said the adherence is a lot higher the needles you know I have used BBC injectables as well a while back a few years ago but yeah it was just a hassle to you know
16:38
formulate it to make it a proper ratios with the the water uh injected clean the needles etc like every day it's kind of a hassle so i wouldn't imagine injecting bbc for any longer than a few weeks at most whereas with the oral peptides you can you know you probably don't want to take them all the time anyway but you know it's much easier to just on and off take them as a as an oral route and even if it is slightly less bioavailable then and
17:06
then it still works because you're more consistent with it compared to missing out on your injectable BBC every few days.
17:17
A hundred percent. That's exactly why we do it. And liposoming them too is something we developed. So that also improves the bioavailability, protects them. And then, you know, how liposomes work, you can shuttle peptides in through them too. So that's another innovation that we have been doing for about a year to make things like the GHK copper work orally. You can use it non-liposomal, but then it's only going to have like a local effect on your stomach.
17:43
on your gastrointestinal tract. We don't liposome it in our GI repair for that specific purpose. People use it in skincare. It's one of the most commonly used peptides in skincare now, and that's because your gut's like your internal skin. So if you liposome GHK, then it's going to end up systemic and work for the anti-aging benefits and kind of work on your skin from within. But if you want it to work on
18:09
via the same mechanism for how it improves your collagen and your elastin in your skin. But if you want it to work on the gut lining and help restore that, then you don't want a liposome. So being intelligent with how you A, protect the peptides, but B, what forms you use and if you liposome or not, or if you use a delayed release capsule or not as a way that you can make these things work really well. And the epitome for that for me is the Neuro Regenerate product where
18:35
we have dihexa, which will work to maybe 5% of what you take if it's not liposomal. It will actually get in the brain and you'll have effects. A lot of people have tried dihexa in the past and said it did a little bit or they noticed something or they had to use it as a cream to really get any benefit. And that's one way of doing it. An intranasal spray is another way, but
18:56
I've found personally since using it in the liposome, it's just been an absolute game changer for my cognitive function. I lived in mold for about three years, so I definitely had some level of brain damage or hippocampal atrophy, which has been proven to happen. You can do brain scans to prove it. I didn't do that, but I just know I couldn't string a sentence together properly during that time. So there was definitely some level of inflammation because of the sinus cavities that actually ended up colonized from the mold.
19:23
So I bought that product out to basically rectify and remedy the damage that the mold caused to my brain that I'm absolutely certain occurred. Gotcha. Yeah. Maybe let's go through some of these products as well. The ultimate gut repair is very interesting. So usually people use PPC.
19:44
for joint healing, but yeah, BPC also has gut healing properties. And this particular product has BPC plus a few other peptides. So yeah, we can walk through what's the rationale behind these ingredients and why do they work for the gut?
20:03
Yeah, of course. Like BPC administered orally is going to preferentially be used by the gastrointestinal tract, by the lining of your small or large bowel. That's just pharmacokinetics 101. If you want it to be somewhere, even if you had like Crohn's and colitis and you had like a distal interstitial
20:21
injury site. You can even do something like a suppository or an enema with the injectable BPC, and that can work as well. It directly gets to where the issue is. But the other way, like these capsules, they will survive the stomach acid. We buffer the capsules with bicarbonate to prevent the acid from activating the pepsinogen to pepsin conversion, so that protects it there as well. And then once they get through, the BPC works on
20:48
At the cellular level, that's a really blanket statement, but it basically works on the health of the cells of your intestines while we synergize it with other peptides like KPV, which is an amazing immunomodulator.
21:02
immune modulator. It potently deactivates the NF-kappa-beta inflammasome, and it's been studied in Crohn's or Crohn's or colitis. I can't remember specifically which one it was off the top of my head, but one of the two IBDs, it had really promising results. So those two peptides, along with the GHK, work on the actual health of the cells themselves. While we use a novel peptide that's not actually naturally occurring, but it's
21:29
called the rasotide, and this antagonizes zonulin. And zonulin, essentially, for anyone who doesn't know what that is, is a biomarker that is essentially a permeability marker. The higher your zonulin levels, that directly correlates with increased intestinal permeability, but also increased blood-brain barrier permeability. Zonulin acts systemically. Anywhere you have tight junctions in your body, of which they're in your gut, they're in your brain, liver and kidneys as well,
21:56
zonulin will increase the leakiness of these sites, but primarily in the gut because that's where
22:02
Most of the things that trigger zonulin are based, i.e. gliadin from eating gluten and pesticides like glyphosate have been proven to also increase zonulin levels, antibiotic use, alcohol, all these things drive that up. So by combining lorazotide, which will essentially block the mechanism of zonulin, it's like bringing in staples on a wound. Maybe you've got a cut on your arm for an analogy. The zonulin is the staples while the BPC and the KPV are
22:30
And the GHK work on actually healing the wound, which for people with IBD, it's literally like they have a wound inside of their gut. So formulating with these things in mind and then combining it with other mechanisms that aren't peptide-based like tributyrin or butyrate is directly fuels and propolis.
22:52
provides health to the cells of the enterocytes. It's been studied pretty extensively now. It's a fantastic single ingredient. If you were to just take one ingredient for gut health and you were budget restricted, I'd recommend butyrate.
23:04
sodium, magnesium, or tributyrin. They're really fantastic for nourishing the cells of your large bowel specifically, but also the small intestines just by providing that direct fuel for the gut lining. The other ones we use are quercetin or quercetin, depending on where you are and how you pronounce it. This is an antihistamine and it has a sealing effect on the gut lining.
23:28
And finally, zinc carnosine, very commonly used by naturopaths and functional medicine doctors for like H. pylori, stomach ulcers, dyspepsia, and reflux. But the carnosine in the zinc-alkanosine is a really powerful anti-inflammatory too that can work beyond just your stomach. So that product I basically formulated to try and remedy every single part of the GI tract.
23:51
If it's a stomach issue, BPC is first studied for ulcers. So the BPC and the zinc carnosine are going to work on that effect. If it's issues with like IBS, indigestion, IBDs, then the other peptides are going to work down there too, whilst all the other ingredients sort of synergize to provide fuel and anti-inflammatory effects for the gut lining.
24:18
Yeah, it's very interesting how all these ingredients can synergize together and
24:25
And even, have you thought about something like glutamine or something like that? That's one of the most popular gut ingredients. The first ever iteration of my BPC product had glutamine in it, but the studied doses required are in the one to two grams, which as far as capsule go, that's like three capsules worth of L-glutamine when a serving's two, so you'd probably need to up it to five. It just didn't particularly seem like the most…
24:51
bang for your buck is one thing we say or the most efficient ingredient to use. Plus the other thing with L-glutamine is it's, I'd say it works in about 70 to 75% of people. The other 25% have a neuro excitatory effect from L-glutamine and can cause some issues with that too. So all of the ingredients, except for maybe the zinc, some people get a little nauseous from a high dose of zinc. All the ingredients I tried to make as benign and as
25:20
widely usable as possible without sort of having to increase the serving size to a ridiculous number of capsules. Yeah. And you mentioned the BPC was, or it works primarily through, the main way it works is in the gut if you take it orally. Would it have any
25:45
spillover effect systemically on joints and skin or brain or something like that as well. Yes, especially if you don't have a reason for it to be used in your gut lining. It's like a chemoattractant or something. There's a word for it that I can't remember, but basically sites of inflammation in your body is where it will
26:06
accumulate and be used by. So if you don't actually have anywhere in your body that BPC needs to be used by, it'll just circulate around sort of with nothing to do and then be broken down after a few hours. And they last about four hours in circulation before hydrolase enzymes break it down and it's no longer going to be effective. But if you do have a distal injury and no level of
26:29
of gut inflammation, then yeah, it will get into circulation and end up helping that one less than if you were to, again, inject it locally. But
26:39
Often when people buy BPC standalone and they have like a tennis elbow or a carpal tunnel or something, and they don't respond to taking the capsules, they often need to just up the dose to sort of super saturate the amount of BPC they're getting because the gut will use a certain amount of it. And then if it no longer needs that extra amount, if it no longer needs more than it's taking, then it will have that spillover effect, get systemic and help with the injury recovery. Yeah.
27:08
Yeah. And the other peptide most often used for injuries is TB4, if I'm not mistaken. And you have like, I guess, specifically for joint injuries, which is called the Wolverine combo. And the Wolverine stack is often called to be BBC and TB500. So can you talk about TB and BBC combination?
27:36
Yeah, it's essentially the BPC primarily for that connective tissue, the collagen ligaments, all those networks and the TB4 fragment. We use the SDKP, that's the one to four fragment of the parent peptide of TB4. That helps more with the musculoskeletal recovery. It helps…
27:59
prevents scar formation. There's been some studies showing it prevents scarring, which is very beneficial for wound healing. Reduces fibrosis, so just really helps as an anti-inflammatory, as well as cell migration and
28:17
What's the other mechanism? It also has an effect on actin, I believe, in actinomycin in the muscle. So that's one of the ways that it's really more specific for enhancing muscle recovery over just connective tissue, which is what the BPC more specializes in.
28:32
So yeah, that's why, yeah, they're used together. You know, if you have an injury, it's rarely ever that it's not going to be some combination of muscle and connective tissue. So yeah, using them together, you're covering all your bases from a peptide perspective. You then combine it with things like PEAs, what I use as a functional filler in almost every one of the peptide products.
28:52
PEA is like safe turmeric. If people have issues with iron or don't want blood thinning effects, PEA is fantastic because it doesn't sequester iron like turmeric or curcumin can. And it also is significantly less of an effect or an interaction with blood thinning medication. And it works essentially through the COX-2 pathway and through the endocannabinoid pathways too. So on the front end, that
29:20
that PEA is going to give you instant, like within a day or two, pain relief from your injury while on the back end, the peptides are working on those transcription factors, working on transcribing the proteins to help and all the cascades of signaling pathways to help with the recovery. Yeah. One interesting study I found about BBC is that they…
29:49
injured these mice with whatever, like crushed their tendons experimentally. And after they recovered with PPC, the tendons were actually stronger than before. So it's usually you would think that after an injury, your tendons and ligaments are going to be weaker. But based on this, you know, study, they found that the mice actually had stronger ligaments than before, which is very interesting.
30:16
Yeah, well, that's an amazing outcome for people. And again, it feeds back into that philosophical statement I said at the start. If someone gets an injury, they should be able to use these as a professional athlete or even as a semi-professional. Anyone should be able to when they elicit that level of benefit. Yeah, it's…
30:34
It's an amazing molecule. Our body makes it for a reason. The stomach acid is where it's made, and that's because we have a really high level of cell turnover in our stomach because of the acid. It's one of the first places to go when you have chemotherapy. You have issues with reflux and gut issues because of the cell turnover in your gut lining, the stomach being…
30:54
the primary place where you need something like bpc to be produced naturally to help it recover and make sure that you don't have any acid which is the most volatile thing our body makes in our body you don't want that leaking or you don't want to you know an issue with your acid so you need that peptide in the stomach acid itself to induce the um the cells of the of the stomach to repair and to just regenerate as fast as possible yeah um
31:22
what what i've uh like what are the other alternatives for uh joint healing people have it's usually like stem cells or prp but those are like super expensive and not really uh possible to do for a lot of people uh whereas yeah peptides you know yeah they're not cheap they're not as cheap as like your regular supplements but uh the the
31:46
Living with a particular joint injury, especially if it lasts for many years and it never goes away, that's just debilitating and reduces the quality of life quite significantly. I think joint pain and injuries are one of the most debilitating conditions.
32:04
you can have in your everyday life. Maybe the number one would be headache or toothache or something like that, but joint pain and aches. If you can't use your shoulder properly or your knees properly, then yeah, that's quite a significant reduction in quality of life. Yeah, and what's the Western medical approach? Opioids, painkillers, and then they progressively need to be ramped up and get stronger and stronger and you end up on opioids
32:30
on the conveyor belt of drug intervention rather than, oh, let's try some natural anti-inflammatories. Let's try the turmeric, boswellia, PEA to sort of work on the inflammation. But if that doesn't resolve or if you need to be on those things forever, then bringing in a peptide to actually work on why you need anti-inflammatories could be a game changer for people. Yeah.
32:52
Maybe now let's move on with some brain peptides. And, you know, BBC has some brain effects as well, but there are a few other more specific neuropeptides. Yeah, well, all the angiogenic effects, let me clarify, angiogenesis is a hallmark of cancer, but it will not…
33:11
cause cancer. I often get that so many times on the customer support or on Instagram, does BPC cause cancer? No, it would not. It induces angiogenesis for the process of healing. And again, like I said, if you don't have the need for it, it won't induce that. It's not going to force angiogenesis like a drug. It will just be broken down.
33:30
But anyway, so that's how one of the mechanisms for how it can help with brain health is improving blood flow by the angiogenic process. If you've got a TBI or an area of your brain that's not getting enough oxygen, then that's one of the ways the peptide might help. The other way is it has neurotransmitter modulating and neurotransmitter receptor upregulating effects. So it helps increase GABA.
33:55
which is why I've often got reports of people taking it and getting improved deep sleep scores and improved aura ring and whoop band scores when they take it, probably via that GABA mechanism. But also, I just believe when you take a peptide like BPC and it works on your gut health, that's going to have such a huge ripple effect for the rest of your body by reducing that in
34:17
inflammatory state that might be simmering away in your gut because 80% of your immune system is based around your gut lining and if you reduce the burden on the immune system then the inflammation that might be you know a 3 out of 10 can drop down to a 1 or a 0 if you don't have that lingering gut issues or if it's significantly worse than that then you are going to have that bright
34:40
gut-brain connection being broken by inflammation and distress in your gut. So that's another way I feel like it indirectly helps the brain, but the GABAergic effect of it as well as helping with, I believe it helps to some level the neuro, what do they call it, the synaptogenesis, like synapt density of dopamine. So people who have had issues with excessive dopamine or there's some studies on it with people
35:09
People who take like cocaine and really dopaminergic drugs, I'm using it to help resensitize them and help them come off of those substances. So it's a very beneficial, it's a multi-beneficial peptide. It's the Swiss army knife of peptides, but other ones that are really beneficial are ones like C-Max and C-Lank. They're sort of more nootropics than I'd, with a side benefit of helping with the synapses and neuroplasticity.
35:38
I love C-Max for verbal fluency, increasing acetylcholine. When my acetylcholine is high, I feel fantastic. I feel like I don't have to worry about recalling mechanisms as much or finding my words and things just come to me and flow a lot better. So acetylcholine is one of my favorite neurotransmitters to push with ingredients like alpha-GPC or peptides like C-Max. C-Lank is kind of
36:03
The opposite of pushing the brain, it sort of relaxes it as an anti-anxiety effect. We don't sell that with Level Up, but it's just one I need to nod my head to. I believe it's a very beneficial one that people could explore as an alternative to antidepressants if they were on the fence about whether to do them or not. I definitely implore people to look at that one and some naturopathic things like saffron or St. John's wort would synergize well with that one. The big ones that I love though are dihexa.
36:32
It's 7,000, I believe, orders of magnitude more potent than endogenously produced BDNF. So BDNF, miracle growth factor for your brain, basically helps with all of the good things that you want to happen in your brain. Neuroplasticity, neurogenesis, synaptogenesis, myelination, it's the Swiss army knife of peptides for the brain. It's a neuropeptide that
37:00
for me personally, has brought back my brain function so significantly alongside of P21, which is one of the active peptides found in cerebral isin, which cerebral isin is derived from porcine brain extract. So when you take cerebral isin, you're taking an extract from pig brain, essentially, which some people for religious reasons can't do that. But also some people for, I guess, some level of
37:27
skepticism over injecting something from an animal's brain is is fair so if you just isolate out the p21 then you can get majority not all of because some of the peptides that are in cerebral isin haven't fully been explored but that one appears to be the most beneficial of the peptides and it increased that one by itself p21 increases um
37:51
elevates BDNF expression two and a half fold. So it will increase in endogenous BDNF while dihexa has extraordinary synaptogenic activity and is, yeah, seven orders of magnitude. So about 7,000 times more potent than BDNF that's produced by our body. So that's a really potent drug-like peptide that can really help people, especially people who've had traumatic brain injury or were looking to prevent neurodegenerative conditions like
38:19
Alzheimer's, Parkinson's, dementia, all those things. I believe this could be the future of medicine for those things because at the moment with dementia and Alzheimer's, there's not really any drugs that are doing a whole lot of long-term benefit. So we definitely need to start looking at these. If a pharmaceutical company decided that they wanted to take on dihexa and modified it and made it a drug, I would have no
38:44
issues with that whatsoever. I believe the studies on that one certainly need to be done. And when you're studying the brain and those conditions, it's certainly going to be an expensive one. So I combine dihexap21 and C-max in liposomes to get them into the brain better with the best of what I learned from naturopathy. Nasset, which is NAC, but with an ethyl ester group
39:08
It has superior pharmacokinetics for absorption, so you don't need anywhere near as much Nasset to increase your glutathione levels. The other thing that it does better than regular NAC is cross the blood-brain barrier, so you can increase glutathione levels in your brain with Nasset or NACit, however you want to say. And terastilbene is another fantastic ingredient.
39:29
isolated compound from blueberries. So all the food and nutrition-based research saying you should eat blueberries to prevent cognitive decline. Well, there's a lot of compounds within that, but terastilbene has been isolated out and started to be one of the most potent anti-inflammatory antioxidants found in blueberries that has an affinity for the brain as well. Ginkgo, bacopa, gotu kola, lion's mane, all of the ones that
39:55
your audience probably already know about or included in that too and because they just work. There's decades of studies showing how they improve brain function, not necessarily around the context of Alzheimer's or dementia. I mean, they probably are, but my perspective
40:10
purpose for those is just to increase, improve neurotransmitters favorably for those conditions and increase blood flow to the brain. Like nitric oxide is so important. A lot of the benefits of exercise for preventing onset of Alzheimer's comes, I believe from the blood flow enhancement and the nitric oxide benefits as well. So that's my attempt to remedy Alzheimer's because, I mean, I can't say that it's a brain support product. And yeah,
40:38
Yeah, my opa, I'm Dutch, he died of Alzheimer's and I saw the deterioration. It came on very heavy and hard and fast. So my dad actually started to present with some symptoms of it. So that's…
40:53
one of the two reasons why i bought it out one i wanted my brain to work as best as i possibly could get it to work and then two to help him and prevent him from going down that path so that's the rationale behind that product yeah with the nac ethyl ester that's yeah like a i like that choice as well it's very interesting because you need a smaller dose than regular nac and
41:17
you know, to get an efficacious dose of regular NAC, you need something like three, five grams or something like that. And, you know, as a capsule, you know, there are like these Glynac supplements out there in a capsule. But yeah, to get an actual effective dose, you need to take something like five to 10 capsules of that. Whereas with NAC ethyl ester, you can, you
41:42
bring it down to just the single capsule and like 100 milligrams, 200 milligrams already has equal effects. So yeah, I'm myself looking into utilizing NAC ethyl ester myself a lot more often. Yeah, it's one of my favorite ingredients. There's a lot of new age, I call them new age or next generation supplement ingredients and that fits alongside of that for sure. The other one you could use is GGC, which is the intermediate step between NAC
42:10
NAC to glutathione conversion. It's like the middle step. That one you could use as well to increase glutathione levels without needing anywhere near as much NAC. NAC's bioavailability is pretty low. A lot of the products and supplements where you need gram amounts, it's because only 1% to 2% to 5% of it get absorbed.
42:27
So that's why you need to dose up high to account for that loss and get an actual systemic amount of it. The other ingredient that I think your audience and yourself would be interested in, you might have spoken about it, I'm not sure, but similar to Nasset, it's the precursor. Nasset being the precursor to glutathione, guanidinoacetic acid or GAA being the precursor to creatine is the other one that I really like. In studies, it was shown to increase
42:56
muscle levels of creatine when taken concurrently with monohydrate, I think it was 8.45 times more effectively. So you get about a 16% increase in muscle creatine levels after a month of consuming GAA alongside of monohydrate versus 2.9 with standard monohydrate. So creatine is actually called methyl guanidinoacetic acid and GAA
43:22
GAA is guanidinoacetic acid. So GAA you can get from the diet and your body will make it and then it will have to methylate the GAA to make it in creatine intracellularly.
43:33
So if you do ever take GAA in isolation, there's a good chance you'll burden your methylation pathways and potentially increase homocysteine levels. So for the product that I created with GAA in it, I included trimethylglycine to sort of provide methyl groups to reduce that risk and increase creatine levels that way. Yeah, and creatine is also good for the brain as well.
43:58
Yeah, that same study that found the 16.9% increase in muscle creatine also looked at it in the context of the brain. And it didn't outperform creatine as well in the brain as it did muscle, but it did increase creatine levels by 3.9 times more, that combination, than monohydrate alone too. And I believe the GAA with its four transporters intracellularly versus monohydrate one, I believe that's
44:26
why it's so much more effective at increasing creatine levels intracellularly in both the brain. Gray and white matter, they studied it, and the average across those two was like 8% increase versus two or something around those numbers. I don't remember them off the top of my head specifically what they were, but it definitely shows a profound ability to increase cellular levels of creatine. It piggybacks on the taurine GABA study
44:56
and creatine transporters. And it also is small enough to work via passive diffusion, whereas monohydrate or any of the forms of creatine have to work only by the CT1, the creatine transporter. So that's why that's one of my favorite ingredients now across all of supplements. Yeah, interesting. Another one of my favorite…
45:18
Brain peptide, as you could call it, is epitalin that supposedly helps with the pineal gland and rejuvenating melatonin production. That's one of the most interesting aspects about it for me, that with age you see a decline in melatonin and possibly you can reverse that with epitalin. And you have epitalin in one of your products as well.
45:41
Yeah, I mean, the primary goal for including that one, it's in a product called Longevity. And that's because it's the bioregulated peptide that was shown to enhance the telomerase activity, maintaining telomere length, essentially. So that's why I included it. But yeah, it's really interesting that it has that effect on melatonin and circadian rhythms too. And that's definitely…
46:05
a very good side benefit to it being in that product. I should probably just bring it out solo or maybe put it in a sleep formulation or something like that along with some of the other bioregulators which are also another interesting and very amazing all the studies and all the research that's gone on for the bioregulators in the past sort of
46:25
60 years or so out of Russia that are only now sort of starting to last sort of three or four years starting to hit some level of interest amongst the biohacking crowd and the functional medicine crowd. But yeah, there's a lot of bioregulators out there and people swear that they work amazingly. I think the peptides tend to work a little bit more noticeable, whereas the bioregulators are more a progressive approach.
46:48
subtle improvement in health. If you take a P21, a Dixer, a C-Max, you're going to feel it very quickly and very effectively. Whereas the bioregulators might take a week or two to notice a subtle effect, but it's still beneficial for your health. Kind of like taking regular old naturopathic herbs, you know, they might taste gross and they might move the dial slowly. But ultimately they work more, they work similarly to the peptides where they help
47:17
transcribe for proteins that are eliciting a benefit in your body and yeah the epitulons probably the best I believe of all the bioregulators and that's why it's the only one I use in the range so far yeah I definitely would be interested in
47:34
Starting to use it, especially as I get older, you know, let's say in 30 years. Hopefully we'll have like some more powerful medicines by that time. But yeah, epithelium is quite interesting to use right now. One of the possible options for the brain and telomeres.
47:51
I'm sure for the anti-aging protocols, we can follow the lead of people like Dave or Brian Johnson. Whoever appears to have aged the best will use that as proof of their concept and follow it when we're a bit older. Yeah, well, you know, with all these things, it's like you need to use what's best available right now.
48:10
In 20 years, hopefully we'll have some actual geroprotective drugs. And I'm not even talking about repamycin, which is the greatest possibility to be a geroprotective drug right now. But we'll hopefully have even more powerful drugs in the future for longevity. I reckon it'll look like gene therapy, to be honest. The phallostatin therapy that's the first of its kind that's being…
48:37
adopted by a lot of biohackers. I'm still on the fence whether I love it or hate it, but
48:42
I think in principle, if it can be done safely and studied for maybe five, 10 years before we just go full cowboy with it, there's a lot of benefits to those ones. There's also another way to, I believe it's a combination of that with peptides, with other drugs that will elicit the best anti-aging effects. A lot of the NAD things, I feel like they definitely are going to help and the studies seem to support that.
49:09
NMN, NR, injectable NAD or liposomal NAD, but there's peptides too, like small molecules that are categorized like peptides, like 5-amino-1-MQ that will inhibit the breakdown through the methionine cycle of nicotinic acid, which is essentially NAD when it's broken down by sirtuins, which is why we
49:33
want to block sirtuin activity to keep our NAD pools high. When it is broken down by the sirtuins into nicotinic acid, there's another enzyme called NNMT that clears it out of our body.
49:46
The small molecule 5-amino-1q inhibits that one and sends it back into the NAD salvage pathway. So that's like a backend way of increasing your NAD levels, whilst on the front end, you can take things like your NMN or your NR or just regular B3 to increase the…
50:04
precursors that way. And then for the sirtuin active, for the sirtuins, things like fisetin, apigenin, quercetin, all the bioflavonoids, all the anti-inflammatories, things that synergize alongside of it. That's a really good way to increase NAD levels. But NAD is just one of the
50:22
primary ways, but not the only way that we can increase lifespan, like the telomerase, for example, and just an overall reduction in what our baseline levels of inflammation, what our cytokines are at. Like when I was in mold, I feel like I aged about 10 years in three years because of the chronic inflammatory condition that I was in that I could not supplement my way out of. I could not eat my way out of it. I had to leave the
50:47
place we were living in the area we were living even before I started to see any improvement in my liver enzyme function and my CRP and ESR all those were elevated despite having some of the most advanced supplemental tools and eating all organic and pure foods none of it really moved the dial enough to undo the damage that mold was doing to me so
51:11
Yeah, I think it's going to be a lot harder to age gracefully with mold being such a prominent issue now across the world. Poor building materials in combination with high levels of EMF, which increase the rate of growth of mold, will make it something I think maybe half of the population will have to navigate at least at some point in their life, probably more though.
51:33
Yeah, yeah, it's quite damaging. My wife also had some mold issues. Maybe I did as well, because I lived in a moldy house for like two decades. But I don't know if I experienced… I didn't experience any symptoms, but maybe it still had like some underlying effects that I didn't notice. But yeah, she was like…
51:57
She used the cholesteramine, which is one of the drugs used to help with mold illness and lowers cholesterol. That's the main effect, but the side effects are that it helps with this chronic inflammatory syndrome and mold issues. Yeah, yeah. Mold's one of those things that can actually tear relationships apart because you're constantly neuro-inflamed if it's affecting you. And the
52:20
The genetic variance in which people actually are susceptible to the effect of mold is quite large. It might be HLA genes, for example. They're the primary ones involved in clearing mold, methylation status, comp status, all the things that you would look for on a Dutch test for hormonal clearance.
52:38
to some level will affect how well you clear your the mycotoxins um if it's colonized in your sinuses like under my eyes have been dramatically affected because i actually had to do sinus cleanses for about three months to clear colonized mold after we'd moved out of our first home um that can be something that you get you might get and your partner might not um
53:00
hormonal imbalances can come from at my testosterone level plummeted to less than 300, which was catastrophic for my libido and my mental health. And I feel like when men have a really low level of testosterone and mold toxins are highly estrogenic too, that's when you have the symptom picture of a really angry, roid rage man, more so than high levels of T that are actually within a good level of
53:25
within a good range without being counterbalanced by too much of the metabolites of estrogen, the fours and the sixteens and the bad ones, so to speak. So
53:36
The way it affected relationships with liver as well, like my liver was constantly backed up, bile became quite sludgy and bowel movements frequency reduced or they can increase too. It's very diverse and very wide hitting the effects of mold. And yeah, if you live close to the ocean or somewhere where there's a sea breeze and you're constantly getting moisture in that way, or you live in a tropical environment, there's a good chance you'll have to deal with it at some point. And colorectal
54:05
Like cholestyramine or chyazin, I believe, is a natural alternative to it. Basically binds to the bile that is the primary method in which your body detoxes mold. So by getting bile flowing with things like bile acids like Tudka, phosphatidylcholine, all of the choleric compounds,
54:28
collar gogs the bitters that's a fantastic way to make sure you're detoxifying mold and if you're still in it you need to keep it moving it's the it's the one life jacket i'd recommend to people is make sure lymphatics and um drainage are sorted and your bioflow is part of that so yeah are there any muscle building peptides body composition peptides out there
54:52
Yeah, injectable ones, CJC, ipamoralin, tesamoralin, all the growth hormone secreticog ones. There's some that supposedly increase testosterone levels, but they're really, really deep in the early stages of research and development. And there's no way in hell I'm bringing out one of those yet until it's gone through some more testing and studies. I don't really want to make people my guinea pigs. Right.
55:17
As far as testosterone, I think the best you have is if you're at that stage, TRT is good for people. If you're not at that age level and you still want to have kids, then naturopathic things like Tonkat Ali are
55:29
Anacyclis, pyrethrum, sustance, tubulosa, shilajit, all those have been pretty well studied and well used now to improve LH and indirectly increase, well, sorry, upstream increase your testosterone levels whilst taking the foundational things, the boring things that people don't really think of as exciting like boron, for example, or magnesium.
55:53
things to reduce sex hormone binding globulin zinc levels as well like they're the foundational things i believe for from a supplement perspective to get your testosterone optimized so that's why i actually made the test boosting product i had because of my t levels dropping below 300 and after two months of taking it they were up in the 700s which is not where i want them to be but it's significantly better and made a big impact on my life too having them
56:21
closer to the ideal range rather than being less than half of where I want one of them to be. Right. Yeah. And sleep and vitamin D, sunlight exposure, those are very underrated for testosterone. Interestingly too, mold affects libido by reducing alpha-MSH. The melanocortin system of your brain gets completely derailed.
56:46
That's why KPV as a peptide is like the master of the anti-mold peptides. KPV is a fragment of alpha-MSH. It is the anti-inflammatory one. It's fantastic for candida overgrowth, for mold illness.
57:02
And that is derived from alpha-MSH. The other ones that are derived from alpha-MSH are, I believe it's called PT-141. And that's like the libido peptide. So if you're having mold, your libido is going to plummet because you're not endogenously going to get that peptide breakdown from the alpha-MSH that's now no longer being used. And then methamphetamine.
57:26
Melatonin actually drops too when you're in mold. The neuroinflammation basically robs you of your melatonin levels, which melatonin is an antioxidant as its sort of other effect. So if you constantly have that sinus cavity problem,
57:41
induced or even it doesn't even have to be in your sinuses it just could be on your roof it's trickling down you breathe it in they're small enough to get in your brain your melatonin levels are going to plummet because it's being used as one of the antioxidants in your body to sort of quench that inflammatory burden that the mold's inducing so that's often why we see sleep libido and immune system issues when you're around mold too so yeah
58:07
um one interesting ingredient that um there was a lot of at the austin summit as well uh like every uh drink there was was with paroxantin and uh our common friend sean wells actually created that molecule and it's supposed to be uh like a
58:30
the same molecule as caffeine but without the negative side effects of caffeine so you get a nice smooth energy increase and alertness increase without the crash and without the jitters and yeah you know i tried it myself you probably did as well there were like these drinks with paroxanthine um and uh you know i do do you think they had obviously an alert similar effect as caffeine like this um increased alertness effect so uh what do you think about paroxanthine
59:00
Yeah, that's definitely a prime candidate, if not one of the top five for the new era, next generation supplemental ingredients. By removing the theophylline and the theobromine, you don't tend to get the heart rate elevation or the anxiety. Those are the two that are attributed to those. It doesn't hit me as hard as caffeine does, but
59:22
I still like the 50% to maybe 75% if I do a heroic dose of it, increase in alertness. Without that crash too, that is the biggest part of it. There's no crash on the other end of it. It's also been well studied to be highly dopaminergic, so it really helps with motivation and neuroprotective and increase BDNF too, which is interesting. So Sean's done a really good job of bringing ingredients like that, like dihydroberberine to the market.
59:50
albaba all of his ingredients are absolutely amazing and i've got a lot of respect for him bringing out the ingredients that i love to use in my formulations i actually have a lot of his ingredients but they have clauses where if you use peptide with their ingredient you can't claim that you use their ingredients so we do have them but just not listed so all the uh dihydroberberines and um uh what are the other ones i got um
01:00:18
Albaiba, all those are his ones just off the record. Gotcha. Yeah, I also noticed that it does work similar to like a cup of coffee, but with caffeine you probably notice that it works more because of maybe the increased heart rate and this adrenaline. So yeah, the paroxanthin increases your wakefulness and alertness, but you don't feel like you're in a more sympathetic state, like you're less…
01:00:48
I guess, adrenergic and less aroused in that sense. So it's a good thing for some situations, but on other cases, I kind of like that small adrenaline rush with caffeine still. So I probably won't be seeing myself completely replacing caffeine with paroxanthin, but paroxanthin is very good if you're
01:01:10
want to increase your wakefulness and alertness let's say in the afternoon you don't want to disrupt your sleep and you don't want to get this adrenaline response too close to bed for example
01:01:21
Yeah, and by not having that high adrenaline response, then that's when you're not going to end up running into burnout if you do take the product every day. A lot of people need more and more and more caffeine or even the other alternatives to caffeine, they still do increase your catecholamines, your adrenaline or adrenaline levels, which for…
01:01:42
a short amount of time is actually one of the best feelings you can get. Like when you've had a cold plunge or something like that, that will increase your catecholamines. People who feel amazing having done a ketogenic diet for the first time, a lot of the time, I believe, is they actually have an increase in catecholamines. When I was doing keto, I did a…
01:02:05
organic acids test and found my catecholamine levels, my breakdown metabolites of adrenaline and noradrenaline were very high from that diet. It was rather stressful on my body. And that's why I tend to not do it for more than a month because I don't want to run into burnout like it actually caused for me.
01:02:23
But yeah, that's part of the reason why a lot of the stimulant-based pre-workouts, like it's ridiculous how high people, companies are running caffeine now. There's some that have like 500 milligrams per day.
01:02:35
scoop and people are double scooping it and I'm just like, you're going to need some adaptogens and some B vitamins for the next six months to undo the one month of using that product. Part of the reason why caffeine is a fat loss agent is that exact mechanism. The catecholamines do improve lipolysis and fat breakdown. It's part of the stress response as you need to liberate fatty acids for
01:03:03
fleeing and using as fuel to fight for this fight or flight response that you've induced by taking too much caffeine or doing a chronic cold plunges. Like I'm not saying these are bad. Everything has its place on the bell-shaped curve, too little, too much. And also depending on all the other stresses in your life. I'm not, I just want to be clear. I'm not saying throw out those good things, but too much of a, too many stresses can definitely make something that's good for you. Something that isn't good for you anymore. Yeah.
01:03:32
Yeah, these pre-workout supplements, you know, if I were to take them every workout, like I would get no sleep almost at all or something. Because yeah, they're like one scoop can be 200 milligrams, even higher than that. And usually I might get 200 milligrams for my total caffeine intake for the entire day. So I'll use it only like if I need to.
01:03:53
get a really good workout or if I'm going to hit a PR or something like that. Yeah. I love the paroxysm for the later on, but for actual workouts, yeah, caffeine I do prefer because I want that cortisol deliberately. So the cortisol, the catecholamines deliberately, but also alternatives like dynamine, for example, I really like the effect of that. It does have a bit of a crash, but
01:04:14
At least it sort of only lasts as long as my workout lasts. I think the duration in which I feel dynamine is maybe one and a half hours to two maximum versus caffeine can linger for maybe four to five before it starts to die off or maybe less if you're more accustomed to it. But anti-acrine is another one that sort of works along the same mechanisms and lines as that.
01:04:36
So those caffeine, tea, cream, dynamine and paroxanthin are all interesting ways that you can get
01:04:45
let's call it energy, even though energy is probably more to do with mitochondrial support, but alertness and awakefulness and what you need to get going in the gym for performance. So yeah, these are all, I love formulating and I love supplements because I just like the ability to at will change my energy levels or my neurochemistry or support a system in the body. And that's why I'm having such a good time formulating and running Level Up Health.
01:05:15
Yeah. Are there any other ingredients worth talking about? Peptides or something else?
01:05:23
Um, that's a good question. I guess one that I really like and you as well is magnesium L3 and 8. There's a lot of really good forms of magnesium. I believe that's interesting because it's one of a few. It's not the only one. I found a few others that can get into the blood brain barrier, but that's still the best well-studied dose of magnesium L3 and 8. The next best form of magnesium that I really like is one called sucrosomal or ultramag if you use that one.
01:05:52
No. So a sucrosome is essentially like a sucrose liposome. They use magnesium oxide, which is almost like 45% magnesium to 55% oxide. If you take it external to having it in a sucrosome, it won't absorb. It's terrible absorption and you'll have laxative effects from it. But what they've managed to do is encapsulate it, but essentially the exact same way you'd use a liposome.
01:06:18
but with the magnesium oxide in the middle of a sucrasome. And this makes it incredibly highly, it significantly improves the bioavailability of it and allows you to get for a very small dose, let's say you want 300 milligrams of elemental magnesium, you'd only need like one 700 milligram capsule of sucrasome or magnesium. So that's my new favorite form for rectifying magnesium deficiency.
01:06:44
If you combine it with some of the other forms like magnesium L3 and A to get that in the brain, then I feel like that's a really good two-ingredient combo. I don't necessarily buy the hype that you need every single form of magnesium. I believe it's more about increasing elemental magnesium in your body and making sure that it gets to where it's needed. And for me, I want it primarily in my brain, especially with
01:07:10
voltage-gated calcium channel-induced issues that EMF cause, it's a really good remedy for people with EMF sensitivity is to take a magnesium L3 and 8 because the magnesium will help balance that calcium efflux which occurs when you're in a high EMF field, like if you're flying, for example, or if you've
01:07:31
using Bluetooth headphones, or if you're so sensitive you can't go into cities, then like a methylene blue and a magnesium L3 and L8 are a really good combo for supporting your brain, its mitochondrial efficiency, but also mitigating the effects of EMF, I believe. Yeah, that's interesting. Yeah, I like magnesium and most people need actually more than the RDA, I would imagine, that the 420 milligrams a day is
01:07:59
it's most first of all most people don't reach that even and they probably need more maybe like 500 600 milligrams yeah especially if they're taking half a gram of caffeine a day it's just double that magnesium requirement because the adrenals are gonna are definitely gonna need that to support them yeah um yeah anything uh else before we wrap up
01:08:22
We'll leave it at that one. I think there's a few more peptides I have, but we'll chat about that another time, maybe in the future. There's like some weight loss ones, Sloop, there's Tessafenazine. It's probably about a 20 minute rabbit hole. So we'll save that for another one. Yes, that's a good idea. Well, yeah, before I ask my last question, where can people learn more about you and your work?
01:08:44
Yeah, I'm a website, leveluphalth.com. And on Instagram, when our Instagram ban is revoked, apparently talking about terkesterone, a plant steroid, gets you a two-month ban. Terkesterone? That's interesting. That's very benign or very commonly discussed.
01:09:05
discussed by everyone yeah of all the things we talk about between the peptides neuro bpc injecting peptides on our on our instagram that was the thing that got us so we'll uh you'll be able to find us on there still and message but i mightn't be able to message back for a
01:09:25
yeah, podcasts. I'm trying to do as many like yours as possible and I appreciate the opportunity to be on your show. As I said, I've listened to it for years now and admire what you're doing. So thanks for having me on. Yeah, my pleasure. Thank you. And my last question is, what's this one piece of advice or habit that you wish you adopted sooner?
01:09:44
Um, not being an extremist with diet and supplements, having done maybe six years ago, I tried veganism for a month, felt terrible. Didn't take me long to realize that was the wrong diet. But then I did keto for two years uninterrupted because my mom had cancer and I was supporting her, but I lost about 15 kilograms of, it was very skinny. I was down to like 70 kilos. I'm now sitting comfortably at 95. So doing that for a prolonged period, um,
01:10:13
Burnt out my adrenals. And yeah, I guess I kind of just clung to the ideology of it and thought it was the best way to be. And even though my body was giving me signs that it was probably not serving me to be constantly on ketogenic diet, I just dogmatically stuck with it and then doubled down and went carnival for a month. And then, yeah, I guess…
01:10:35
these are interventions. I believe that I don't believe people should be on them forever. I'm not saying go back and eat gluten once you're finished doing that, or don't care about pesticides and just eat whatever, but I don't like extremism. It doesn't sell well to be in the middle and moderate with things, but yeah, don't be too extreme. And the other part is make sure you're not living in mold. That ruined my life for three years. So yeah, make sure you, you
01:11:01
you take that seriously. You can do things like mycotoxin testing or visual contrast sensitivity testing. That's a free one, I believe, to see if it's an issue. And a lot of the organic acids tests have metabolites for mold too. So if you're familiar with doing that and you see something elevated in that, then it's definitely worth looking at because half of the level up range has been
01:11:22
basically develop from me trying to remedy the issues that mold cause. So rather than having to take seven or nine products to rectify the issues, just don't live in it to begin with. Or if you have, try and get out as soon as you can. It will have catastrophic effects on your health. Yeah, that's a good tip. And yeah, well, thanks for coming to the show and definitely very excited about the peptide space and looking forward to
01:11:50
you know future peptides in the future and uh you know hopefully more clinical trials as well absolutely thanks sim
Edit:2025.07.07
